Drug nanocrystals: A way toward scaleup ScienceDirect
01/07/2016#0183;#32;The wet ball milling process employed for the production of nanosuspension was optimized for process parameters as follows. A 2 3 factorial design of experiments and the knowledge and experience from the previous studies were applied to study the effect of variations in drug content (2%, 5%), milling media size ( mm, mm of yttrium stabilized zirconium beads) and mill rotation